Release date: 2012-10-22
Researchers from the University of California, Los Angeles, Henry-Saxley School of Engineering and Applied Sciences have confirmed that they can manipulate thousands of how to split, change shape and use tiny magnetic nanoparticles that are about 1000 times smaller than human hair. Produces a finger extension. The researchers say the new tool can be used in developmental biology to understand how tissue develops, or in cancer research to discover how cancer cells move and invade surrounding tissues. The results of the study were published in the Nature Methods journal on October 14. Cells are thought to be a complex biological machine capable of a variety of "inputs" and producing specific "outputs" such as growth, movement, division or production of molecules. In addition to input, cells are also extremely sensitive to the location of the input, in part because the cells perform "spatial multiplexing": the same basic biochemical signals are used to perform different functions at different sites within the cell. Understanding the positioning of such signals is particularly challenging because scientists lack tools with sufficiently high resolution to control functions within the tiny environment of cells. Given that the response made by each cell can change, any useful tool will be able to simultaneously interfere with many cells with similar characteristics so that the responses they make are accurately distributed. To solve this problem, an interdisciplinary research team from UCLA, including Dino Di Carlo, associate professor of bioengineering, postdoctoral fellow Peter Tseng, and Jack Judy, professor of electrical engineering, developed a platform to precisely manipulate uniform shapes. Magnetic nanoparticles inside the cell. These nanoparticles produce a local mechanical signal and produce different responses from the cell. To achieve this platform, once the cells swallowed these small particles (each with a size of 100 nanometers), the team first had to overcome the challenge of moving these nanoparticles through the viscous interior of the cells. Using ferromagnetic technology that enables magnetic materials to be turned on and off, the team developed a way to embed a grid of small ferromagnetic blocks on a micro-glass slide and precisely place the individual with the proteins attached to the cells. The cells are in the vicinity of these ferromagnetic blocks, which carry a protein pattern attached to the cells. When an external magnetic field is added to the system, the ferromagnetic blocks are activated, thereby enabling the nanoparticles in the cells to be pulled in a particular direction to evenly align them. In this way, researchers can simultaneously guide and control thousands of cells. Using this platform, the team confirmed that cells respond to this local magnetic force in several ways, including the way they split. When a cell undergoes replication to produce a process of two daughter cells, the axis of division depends on the shape of the cell and its anchor point attached to the surface. Researchers have discovered that the magnetic force generated by intracellular nanoparticles can change the axis of cell division so that cells divide in the direction of the magnetic force. Researchers say this sensitivity to magnetic forces may help people understand tissue formation and stretching during embryonic development. In addition to controlling the splitting axis, they also found that local magnetic forces induced by nanoparticles can also activate a biological process in which cells produce filopodia. With these filopodia, the cells are able to find attachment sites.
Source: Bio Valley
Medical Hand Washing Sink,Hospital Surgical Scrubbing Sink,Hospital Scrubbing Station,Hospital Wash Sink
Taizhou Gaogang District Dixin Medical Equipment Co., Ltd. , https://www.dixinmedical.com