About the choice of high pressure homogenizer

June 18, 2021

About the choice of high pressure homogenizer

At present, high-pressure homogenizers on the market are widely used in bioengineering, pharmaceutical preparations, dairy products, fine chemicals, food processing industries, Escherichia coli, yeast, algae breaking, animal cell biochemistry, enzyme engineering, genetic engineering drugs. , human vaccines, veterinary vaccines, nanometers, emulsions, etc. Imported brands include APV in Germany, NIRO in Italy and ATS in Canada, AVESTIN in Canada, MFIC in the United States, etc. Domestically produced are Shanghai Donghua, Ningbo Xinzhi, Guangzhou Jueng, etc.

At present, the mainstream homogenizers on the market are valve homogenizers: Germany's APV, Italy's NIRO and Canada's ATS have a market occupancy rate of over 90%.

1. Choice of homogeneous pressure: In theory, the higher the highest working pressure, the better, but in fact it needs to be decided according to the needs of the project. Not the higher the pressure, the better:

1, from the perspective of cell breakage: temperature is too high, there are temperature problems: for example, for the German APV, the Italian NIRO and the Canadian ATS three valve homogenizers (with a market share of more than 90%), in Pichia pastoris When the bacteria breaks the wall, the highest pressure selection is generally around 1300 Bar, because the higher the homogenization pressure, the higher the temperature generated by the homogenization (the temperature of the material will increase by 2.3 ° C for every 100 Bar increase), and the temperature will increase. Li has a test for biological activity, so when the homogenizer is selected, the working pressure can reach 1500 Bar , the safety performance is good, and the temperature control is below 10 °C .

2, from the perspective of pharmaceutical preparations, the pressure can be processed more kinds of materials, for example, some liquid emulsions can only be homogenized to below 100nm at 1000Bar, while some medicines, foods, especially liquids, have a certain amount of solids. The suspension of particles, then at least 1500 Bar or more pressure to homogenize to the nanoscale. However, the pressure is too high, but it will affect the stability of the drug. Therefore, when the homogenizer is selected, the working pressure is 1800 Bar (the imported digital display pressure gauge generally has a maximum range of 2000 Bar), the safety performance is good, and the second-level homogenizing valve must meet the GMP design requirements .

2. Minimum feed amount: The smaller the better, the more material can be saved. At present, the raw materials of some medicines reach several thousand yuan / gram, and the user of course hopes to complete a homogenization experiment with a minimum of materials. Moreover, the experiment is a process of repeated iterations. The larger the sample size, the more material is wasted.
3. Processing effect: The user is of course the material that he hopes to make. First, the degree of nanometer level can be achieved. Secondly, the nanometer level is distributed at the same time, and the particles are already dozens of nanometers, and some are still Micron.
In order to solve this problem, it is recommended that the user purchase a homogenizer, and the manufacturer is equipped with a nano-scale filter extruder device, preferably an in-line extruder, which is troublesome to extrude offline.
4. Cleaning and sterilization: The imported high-pressure homogenizer is convenient for cleaning and sterilization. It is recommended to consider cleaning and sterilization online.
5. Do not think about the noise, safety, and the number of users in China. From the user list, you can determine whether a device is selling well. The more well-known users, the better the quality of this device.
6. Manufacturers of homogenizers generally say that their equipment is very good. It is recommended that they provide a list of users and provide them with relevant results and papers.
VII. Security: This is the most important. Any user does not want to have personal safety hazards during the use of the equipment. Therefore, when choosing a homogenizer, they must be provided with quality and safety documents.
Eight, after-sales service: high-pressure homogenizer equipment for a long time in high-pressure working state, of course, can not avoid some failures and wear, when users choose high-pressure homogenizer, the need to consider after-sales service as a vital indicator.
 　　 Through the comprehensive assessment of the above points, I believe that you can compare the various aspects of high-pressure homogenizer equipment, so you can choose a favorite high-pressure homogenizer equipment.

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